Regulatory idiotopes / Constantin A. Bona.

  • Bona, Constantin A.
Date:
[1987], ©1987
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Regulatory idiotopes / Constantin A. Bona. Source: Wellcome Collection.

    14/312 (page X)
    X PREFACE Second, this book presents experimental data supporting the idiotype regula¬ tory concept and theoretical aspects related to the physiological implication of regulatory idiotopes. Finally, this book shows the practical applications of idiotype concepts to the preparation of vaccines, to understanding the basis of autoimmune diseases, to cancer therapy, and to the study of the receptors for hormones, vitamins, and other biologically active substances. The book contains two chapters on new molecular findings that contributed to the understanding of the molecular organization of genes encoding the specificity of the lymphocyte receptor and the idiotypes expressed on it. The second chapter defines an idiotype and describes the relationships be¬ tween idiotypes and Vh gene families. Two chapters are devoted to established subjects with the addition of new information concerning the sources and the postulates of the idiotype network theory. One chapter covers the experimental findings that led to the formulation of and support for the regulatory idiotype concept, and the last three chapters provide information on the implications of regulatory idiotopes in physiological and pathological phenomena. We hope that this information will be valuable to any student or specialist who is devoting his or her labor and thoughts to the understanding of the role of idio¬ types in the regulation of lymphocyte functions and of the relationships between the immune system and other systems in the body. Constantin A. Bona New York, New York January 1987