Regulatory idiotopes / Constantin A. Bona.

  • Bona, Constantin A.
Date:
[1987], ©1987
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Regulatory idiotopes / Constantin A. Bona. Source: Wellcome Collection.

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    Preface The discovery of idiotypes in the early 1960s by Oudin and Kunkel has signifi¬ cantly influenced modem immunology, particularly after the formulation of the idiotype network theory by Niels Jeme. Recently, we showed that in the auto¬ logous system a particular cateory of idiotopes, designated as regulatory idio- topes, plays a privileged role in the regulatory process and in communication be¬ tween lymphocytes and other somatic cells. The aim of this book is threefold. First, the development of molecular and cel¬ lular immunology produced new information to aid in understanding the molecu¬ lar basis of the generation of diversity of the immune receptor as well as of mech¬ anisms governing cellular interactions based on recognition of self-idiotopes. It was our intention to provide an account accessible to researchers in various fields. Information from a variety of experimental systems has been integrated in a coherent fashion to contribute to the understanding of the role of idiotypes as regulatory forces within the immune system. Information integrated in this book is structural because it illustrates the function of the genes encoding the specific¬ ity of the receptor and its idiotypes, dynamic because it shows how the idiotypes function, and spatial because it shows how the cells speak to one another using the idiotype dictionary. ix