The Oncogene handbook / Robin Hesketh.

London : Academic Press, [1994], ©1994. [1995]

xi, 620 pages : illustrations ; 26 cm

Copy 1. Donor: Wellcome Trust Sanger Institute.

Tumour viruses and the identification of oncogenes -- Identification of oncogenes -- How are proto-oncogenes activated by retroviruses? -- How are proto-oncogenes activated in humans? -- DNA tumour viruses -- Normal cell growth and the functions of oncoproteins -- Activation of normal cell growth -- What do oncoproteins do? -- Nuclear oncoproteins -- General consequences of oncogene expression -- Gene therapy for cancer -- Major categories of oncogenes -- Oncogenes transduced by retroviruses -- Oncogenes activated by retroviral insertion -- Oncogenes at chromosomal translocations -- Tumour suppressor genes detected in human tumours -- Functions of oncoproteins -- Chromosome locations of human proto-oncogenes -- Sequence homology within the protein kinase family -- Individual oncogenes -- ABL/BCR -- BCL1, BCL2 and BCL3 -- CBL -- CRK -- CSF1R/Fms -- DBL -- DNA tumour viruses -- Simian vacuolating virus 40 (SV40) -- Polyoma -- Adenovirus -- Papillomavirus -- Epstein-Barr virus (EBV) -- EPH -- ETS -- FGR -- FOS -- FPS/FES -- FYN -- HCK -- HSTF1/Hst-1 and INT2 -- JUN -- KIT -- LCK -- MAS -- MET -- Mil -- MOS -- MYB -- MYC.

(cont) PDGFB/Sis -- PIM -- RAF1 -- RAS -- REL -- RET -- ROS1 -- SEA -- SKI -- SRC -- TAL1 -- THR/ErbA, EGFR/ErbB-1, HER2/Neu, HER3 and HER4 -- TRK -- Tumour suppressor genes -- Retinoblastoma (RB) -- P53 -- Neurofibromatosis type 1 and type 2 -- Von Hippel-Lindau disease -- Wilms' tumour -- Familial adenomatosis polyposis -- DCC -- Cell adhesion regulator (CMAR/CAR) -- [alpha]-inhibin (INHA) -- RNA-activated protein kinase (PKR) -- Metastasis suppressor genes (cadherins, TIMP, NME) -- Integrins -- Prohibitin -- WNT1/WNT3 -- YES1 -- Life cycle of retroviruses; HIV and HTLV.

Includes bibliographical references and index.