Blood-pressure in surgery : an experimental and clinical research; the Cartwright prize essay for 1903 / by George W. Crile.

  • Crile, George Washington, 1864-1943.
Date:
1903
Catalogue details

Licence: In copyright

Credit: Blood-pressure in surgery : an experimental and clinical research; the Cartwright prize essay for 1903 / by George W. Crile. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    24 mm. The administration of Veo grain of strych- nin was attended by a very marked rise in the blood- pressure. After eight minutes a dechne began. The rapidity of the heart was increased and the length of the strokes diminished. The decline then became gradual. Salt solution was again given; strokes in- creased, temporarily raising the blood-pressure. A second injection of -^/sq grain of strychnin was given. A less marked effect than the first was noted. A third injection followed. The blood-pressure was slowly falling. After a lapse of twenty minutes, slight twitching of the muscles was noted. Again there was a slight rise in the blood-pressure. In twenty minutes the blood-pressvire fell and the animal died. Experiment 54. Strychnin. Dog. Ether anesthesia. The animal was reduced to shock by exposing and manipulating the intestines. At 12.26, blood-pressure, 105 mm.; pulse, 168; respiration, 32. At 12.28, ^/cjo grain of strychnin was injected. Blood-pressure, 80 mm.; pulse, 148; respiration, 36. At 12.29, blood-pressure, 100 mm.; pulse, 128; respiration, 32. At 12.30, the left hind foot was burned. At 12.31, blood-pressure, 100 mm.; pulse, 128; respiration, 32. At 12.34, blood-pressure, iiomm.; pulse, 136; respiration, 40. At 12.35, blood-pressure, 120 mm.; pulse, 140; respiration, 40. The rise in pressure was gradual and well sustained. Experiment 55. Strychnin. Mongrel dog; weight, 14 kilos; good condition. Morphine and ether anesthesia. At 1.35, blood-pressure, 140 mm.; pulse, 148; respiration, 24. At 1.40, blood-pressure, 140 mm.; pulse, 144; respiration, 36.