Principles of nuclear structure and function / Peter R. Cook.

New York : Wiley, [2001], ©2001.

xv, 352 pages, 4 unnumbered pages of plates : illustrations (some color) ; 26 cm

Copy 1. Supplier/Donor: Wellcome Trust Sanger Institute.

1. Some Principles. Overview of the Cell Nucleus. A Sense of Scale. Structures of Nucleic Acids. Recognizing Specific DNA Sequences. Making Large Structures. Some Evolutionary Considerations -- 2. Structure. Overview of Nuclear Structure. The Nuclear Membrane. The Nucleolus. Packaging Chromatin During Interphase. Artifacts. Nucleoskeletons and Nuclear Subcompartments. Chromosomes -- 3. Replication. Principles. Replication Factories. The Mechanics of Synthesis at the Form. The Initiation of Synthesis. Replicating Ends -- 4. Transcription. Principles. Tracking Versus Immobile RNA Polymerases. The Three Kinds of Eukaryotic RNA Polymerase. Transcription Factories. Processing the Transport of Polymerase II Transcripts -- 5. Repair. The Need for Repair of Damage. Some Experimental Approaches. Types of Repair. Sites of Repair. Some Consequences of Inefficient Repair -- 6. Regulation of Gene Expression. Simple Regulatory Circuits in Bacteria and Yeast.

Includes bibliographical references and index.