The action of the cinchona and certain other alkaloids in bird malaria / by J.A. Goodson, T.A. Henry, and J.W.S. MacFie.

  • Goodson, John Augustus.
Date:
[1930]
Catalogue details

Licence: Public Domain Mark

Credit: The action of the cinchona and certain other alkaloids in bird malaria / by J.A. Goodson, T.A. Henry, and J.W.S. MacFie. Source: Wellcome Collection.

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    dissimilar actions, or for the grading of a series of substances with actions of the same order, experiments would have to be made with very much larger numbers of birds. Table I. Cinchona alkaloids. Day on which parasites ap¬ peared in blood Dose in mg. ,-A-N No. of daily Control Treated Antimalarial Drug doses given birds birds action Quinine hydrochloride 10-0 x 6 6 — Cured* 5-0 x 6 6-8 11-13 Slight 2-0 x 6 6 14-15 Moderate 1*0 x 6 7-9 16-17 Moderato 1-0 x 6 — 12 Slight TO x 6 6 5 None 0* §5 x 6 5 10 Slight 0-5 x 6 7-8 9 None 0-5 x 6 7-9 5 None Hydroquinine dihydrochloride 5-0 x 6 6-8 — Curedf 5-0 x 6 7-8 — Curedj 2-5 x 6 7-8 — Cured§ TO x 6 7-8 — Curedf TO x 6 5-9 16 Moderate TO x 6 6 14-15 Moderate 0-5 x 6 6 11-12 Slight 0-5 x 6 6 17 Moderate 5-Aminohydroquinino hydrochloride 5-0 x 6 7-8 — Curedf 5-0 x 6 7-8 11-12 Slight 50 x 6 6 12-13 Slight TO x 6 7-8 12-13 Slight 0-5 x 6 6-8 7-8 None Quinidine hydrochloride 10-0 x 6 7-9 22-26 Moderate 5-0 x 6 7-8 26 - II 5-0 x 6 6-8 13 If 5-0 x 6 5-9 19-20 Moderate Dihydroquinidine dihydrochloride 5-0 x 6 6-8 14-16 Moderate Cinchonine hydrochloride 5-0 x 6 7-8 11-12 Slight Dihydrocinchonine dihydrochloride 50 x 6 6-8 11-13 Slight Cinchonidine hydrochloride 5-0 x 4 : 2-5 x 2 7-8 16-17 Moderate** Dihydrocinchonidine hydrochloride 50 x 6 7-8 14-16 Moderate * Re-inoculation on 24th day without effect. Re-inoculation on 46th day produced normal infection, indicating that bird had been cured. f Re-inoculation on 30th day without effect. Re-inoculation on 40th day produced normal infection, indicating that bird had been cured. | Re-inoculation on 26th day produced normal infection, indicating that bird had been cured. § Re-inoculation on 26th day without effect. Re-inoculation on 36th day produced normal infection, indicating that bird had been cured. !| Bird died on 26th day without showing evidence of infection. Bird died on 13th day without showing evidence of infection. ** Dose reduced owing to toxicity. Cinchona alkaloids (Table I). Five of these alkaloids have been compared in bird malaria by Giemsa, Weise and Tropp | 1926] and the results of the two comparisons may be sum¬ marised as follows: