Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
[1910?]
Catalogue details

Licence: Public Domain Mark

Credit: Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale. Source: Wellcome Collection.

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    (4) The optimum carbon-skeleton for sympathomimetic activity consists of a benzene ring with a side-chain of two carbon-atoms, the terminal one bearing the amino-group. Another optimum condition is the presence of two phenolic hydroxyls in the 3:4 position relative to the side-chain: when these are present, an alcoholic hydroxyl still further intensifies the activity. A phenolic hydroxyl in the 1 position does not increase the activity. (5) Catechol has no sympathomimetic action. (6) Motor and inhibitor sympathomimetic activity vary to some extent independently. Of the catechol bases those with a methylamino- group, including adrenine, reproduce inhibitor sympathetic effects more powerfully than motor effects: the opposite is true of the primary amines of the same series. (7) Instability and activity show no parallelism in the series.