Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
[1910?]
Catalogue details

Licence: Public Domain Mark

Credit: Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale. Source: Wellcome Collection.

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    but not virgin cat’s uterus. Such variations of order would be par¬ ticularly probable in the case of the ketones, in which the orders of activity on organs with purely motor and purely inhibitor responses are not identical. It is, indeed, in the ketone group that the varia¬ tions of order with different examples of the non-pregnant uterus are observed. It may be said, then, that the view which regards the effect of these bases on most organs as the algebraic sum of two opposed effects is in accordance with the known facts, the apparent irregularities and variations in the order of activity being to some extent explicable on this view. It has been mentioned that the ratios between the activities of the bases on the blood-pressure vary not only with different animals, but with the same individual at different stages of an experiment. This unequal rapidity of decline in the activity of different bases can be observed very readily in the case of isolated organs. As already stated the exact determination of ratios of activity is not easy in such circum¬ stances: but, on the other hand, the experiment can easily be extended over several days, in which time differences initially slight become greatly accentuated. One striking instance will suffice. A virgin cat’s uterus, isolated on April 15th, gave a marked inhibitor response on that day to p. hydroxyphenylethylamine and its alkylamine homologues, as shown in Fig. 5. It was kept in cold oxygenated Ringer’s solution till April 18th, when, on warming again to 38°, it resumed an active rhythm. It had now, however, completely lost its sensitiveness to the bases with one phenolic hydroxyl, 5 c.c. of — ^ solutions producing no trace of inhibitor action. On the other hand its inhibitor response to methylamino-aceto-catechol was retained without perceptible impair¬ ment. Similar, though smaller differences in rate of activity-decline are observable within the limits of the catechol series of bases, and with the motor response of the retractor penis muscle. E. Amines with three phenolic hydroxyls. Only two of these have been available, both of them being amino- bases. OH OH (1) Amiuo-aceto-pyrogallol HO^ . CO . CH2. NH2. OH OH / \ .CH.,.CH,,.NH2. (2) Amino-ethyl-pyrogallol HO