Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
[1910?]
Catalogue details

Licence: Public Domain Mark

Credit: Chemical structure and sympathomimetic action of amines / by G. Barger and H.H. Dale. Source: Wellcome Collection.

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    Meyer, and presents an interesting analogy. The question whether thi'se tertiary amines really have an action of the same type deserves furtl ier investigation. I he action of the quarternary ammonium salt, hordenine methiodide, is ol gieat interest. A large number of such quarternary bases from alkaloids have been examined by various observers, beginning with Fraser and Crum-Brown, and the generalisation that they have <i curaie action has been weakened by comparatively few exceptions. Fig. 6. At A, 2 mgms. hordenine. B, ,, p. hydroxyphenylethylamine. C, ,, hordenine methiodide. In view of the recent evidence of the physiological antagonism between nicotine and curare (Langley1) it was of particular interest, therefore, to find in hordenine methiodide a quarternary ammonium salt of which the action resembles that of nicotine in almost every particular. 1 milligramme of this salt, injected intravenously, causes inhibition of the heart for a few beats, followed by the characteristic rapid rise of blood-pressure and rapid fall (Fig. 6). The effect is indistinguishable from that caused by 0*5 mgm. of nicotine. The effect 1 Proc. Roy. Soc. B. lxxviii. p. 170. 1906. 3—2