Collagen fibrils

  • Rob Young
  • Digital Images
  • Online

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Collagen fibrils. Rob Young. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Source: Wellcome Collection.

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Description

Transmission electron micrograph showing collagen fibrils in longitudinal view from a patient with glaucoma. The a-e banding is visualised by uranyl acetate staining of charged amino acid residues in the constituent collagen molecules. This specimen is also stained with a cationic dye to reveal interfibrillar proteoglycans. Although the fibrils look normal these proteoglycans are reduced in this area supporting the theory that abnormal proteoglycans are a cause of glaucoma. Biomedical Image Awards 1999.

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