On the action of anaesthetics / by Professor M'Kendrick.

  • McKendrick, John G. (John Gray), 1841-1926.
Date:
[1881]
Catalogue details

Licence: Public Domain Mark

Credit: On the action of anaesthetics / by Professor M'Kendrick. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    o convulsive movements, chiefly of the jaws ancl fore-paws. Anaes- thesia in these rabbits was doubtful. 4. Bichloride of Methylene (so called, but, as it has not a definite and constant boiling point, it is obviously a mixture.—Deputed formula, CH3C12). With frogs, it was found that the heart became quickly affected, and soon stopped. With rabbits, respi- ration rapidly deteriorated and stopped, while the heart was still beating. In an experiment with artificial respiration and exposure of the heart, the heart was weakened and soon stopped, but not so rapidly as with chloroform. As in the case of chloroform, the right ventricle became enormously distended—the first sign of paralysis being the commencement of this distension. 5. Amylene (C5H10) was administered to rabbits both by cloth and subcutaneously. No anaesthetic effect was produced. 6. Butyl Chloride (C4H9C1) administered to rabbits affected respiration, but not very rapidly. In experiments with exposure of the heart, the cardiac pulsations became weaker, and ceased altogether after some time. In one experiment it was noted that, almost immediately after complete anaesthesia, the respirations became shallow, and soon stopped. 7. Ethene Dichloride (formerly named ethylene dichloride, or Dutch liquid, C2H4C12) produced convulsive movements of both extremities, continuing up to death. There was no anaesthesia up to the commencement of the convulsions. 8. Methyl Chloride (CH3C1), which boils at the ordinary tem- perature, was obtained in alcoholic solution in a sealed tube, and allowed to boil off into a funnel, into which the muzzle of a rabbit was inserted. After somewhat prolonged use, there was not any abolition of reflex action, and the animal almost immediately recovered. The only effect was slight drowsiness. 9. Ethyl Chloride (C2H5C1, boiling at 12° Cent. =53‘6° Fahr.), administered to rabbits in the same way as the above, produced rapid anaesthesia; but in one case the respirations soon stopped, and in another, when air was admitted more freely, general con- vulsions occurred. 10. Nitrous Ethyl Ether (C2H5N02) produced great excite- ment and convulsions, almost immediately followed by cessation of respiration. It was apparent that the above substances all presented dis-