Studies on the pathology and on the etiology of variola and of vaccinia / by William Thomas Councilman [and others].

  • Councilman, W. T. (William Thomas), 1854-1933.
Date:
[1904]
Catalogue details

Licence: In copyright

Credit: Studies on the pathology and on the etiology of variola and of vaccinia / by William Thomas Councilman [and others]. Source: Wellcome Collection.

Provider: This material has been provided by London School of Hygiene & Tropical Medicine Library & Archives Service. The original may be consulted at London School of Hygiene & Tropical Medicine Library & Archives Service.

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    and this in cases which give no macroscopic indication of them. Accompanying this general degeneration of the epithehum, there is usually some change in the interstitial tissue, consist- ing in edema and a slight increase in the number of cells. (2.) Focal lesions. — The focal lesions are more numerous close beneath the tunica than elsewhere. They vary in number, some testicles being thickly sown with the lesions, while in others a single lesion would be found only after a number of sections were examined. The foci vary in size from those which are microscopic to those which are five millimeters in diameter. The smallest lesions, and those best adapted for study, are in the undeveloped testicles of children. In these and in some adult cases the beginning of the lesion is found to consist in infiltration of the interstitial tissue with cells. The infiltrating cells are lymphoid, and large, baso- phile mononuclear cells. The vessels are dilated, and cells similar to those in the tissue are found in them. Such foci involve only the interstitial tissue between two or three tubules. No change can be demonstrated in the epithelium, beyond the common degeneration. Nuclear figures are found both in the cells in the interstitial tissue and in those in the ves- sels. No degeneration is found in the interstitial cells. From such lesions as these, which can best be compared with the small interstitial foci in the kidneys, the process extends. In the larger foci the cells in the interstitial tissue are more numer- ous and closely packed in the dilated septa. The lymphoid cells and the large mononuclear basophiles predominate, but among them phagocytic cells begin to appear. These vary in size here, as elsewhere, and their phagocytic qualities are shown by the red corpuscles and other cells enclosed within them. There is some difference between the lesions in chil- dren and those in adults in the greater numbers of eosino- phile cells in children. The phagocytic cells seem to be less numerous in children. The blood vessels in and about the foci are greatly dilated, and contain cells of the same character as those in the interstitial tissue, and there is