An experimental investigation on diarrhoea and vomiting of children / by Edward Mellanby.

  • Mellanby, Edward, Sir, 1884-1955.
Date:
[1916?]
Catalogue details

Licence: In copyright

Credit: An experimental investigation on diarrhoea and vomiting of children / by Edward Mellanby. Source: Wellcome Collection.

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    AND VOMITING OF CHILDREN1 By EDWARD MELLANBY (From the Pharmacological Laboratory, London Hospital Medical College) Synopsis. PAGE I. The object and basis of the re¬ search . . . . .165 II. Experimental procedure . .170 III. Preliminary experiments . . 171 (a) The disappearance of ,8-i from the small intestine . . . .171 (b) The independence of the absorp¬ tion of (3-i in each loop of the intestine . . . . .171 (c) The increasing rate of absorption in passing from the duodeno¬ jejunal flexure to the caecum . IV. The effect of food-stuffs and bile on the rate of absorption of (3 - imidazolylethylamine ((3 - i) from the small intestine (a) The effect of milk (b) „ ,, meat . . . (c) „ ,, fat .... 00 „ ,, carbohydrate . (e) „ ,, water 00 » „ bile on the absorp¬ tion of fat 172 172 172 173 178 174 174 175 V. The effect of MgS04 on the ab¬ sorption of /3-i . . .176 VI. The effect of morphine on the absorption of (3-i . . .177 VII. The effect of alkali and acid on the absorption of /3-i . . . 178 VIII. The effect of altering the volume of body fluids on the absorption of (3-i ...... 180 PAGE (a) The effect of diminishing the body fluids by bleeding . . .180 (b) The effect of increasing the body fluids by injecting Ringer solu¬ tion .181 IX. Some miscellaneous experiments . 183 X. Evidence that /3-i is not absorbed from the large intestine . .185 XI. The resistance of animals to (3-i under varying conditions . . 187 (a) The blood - pressure effects in animals injected with Ringer solution ..... 189 (b) The blood - pressure effects in animals deprived of blood . . 191 (c) The blood-pressure effects in fed animals ..... 192 XII. Summary of experimental results with animals .... 195 XIII. The bearing of the above results on the aetiology of diarrhoea and vomiting . . . . .loo XIV. (a) (b) (c) (d) The bearing of the experimental results on the treatment of the disease ..... The necessity of increasing the body fluids to normal . Feeding. The use of purgatives . The danger of morphine 197 198 200 200 201 I. The Object and Basis of the Research. The following is a preliminary account of experiments undertaken in order to elucidate the condition of diarrhoea and vomiting of children. From a bacteriological point of view, this pathological condition has been extensivel} 1 Giving results of an investigation subsidized by the Local Government Boaid. [Q. J. M., April, 1916.] O