The healing of arteries after ligature in man and animals / by J. Collins Warren.

  • Warren, John Collins, 1842-1927.
Date:
1886
Catalogue details

Licence: Public Domain Mark

Credit: The healing of arteries after ligature in man and animals / by J. Collins Warren. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    reduced the inflammatory reaction to a minimum, this callus-like mass of tissue is found. When the inflammation has been great, it may assume considera- ble proportions; but in cases of suppuration and hemorrhage it will, on the other hand, be found to have broken down and to have left the artery more or less exposed. The thrombus varies greatly in size. In the antiseptic cases it has been reduced to an exceedingly small mass, so small as to be easily overlooked; but in no case has it been absent entirely. Like the external callus it appears to indicate the amount of traumatism which has been produced, but not, however, with the same accuracy, for, in some of the most perfect examples of asepsis, it was larger than in cases in which this treatment had been less successfully carried out. A series of experiments with the double ligature, per- formed to test the question of the activity of the endothehum and wandering cells, is inserted here, to preserve as nearly as possible a chronological order. DOUBLE LIGATURE. One Week. The femorals of a large dog were exposed at two points, each about one inch apart. The sheath was opened only at the point where the ligature was applied: carmine granules were then freely sprinkled on the wound. No attempt at an antiseptic dressing was made. The intermediate portion was compressed so as to empty it of blood, but in one case the attempt was only partially successful. There was a suppurating wound beneath the sutures, at the end of a week, when the animal was destroyed, and in bring- ing the body into the laboratory on that day, a hemorrhage took place from the left femoral at its central portion. A part of the vessel which included the ligatures was removed, cut in halves, and each half split longitudinally. At the proximal end, from which the bleeding took place, a fresh clot is seen occupying its mouth. This clot is concave on its inner surface which is covered by white corpuscles. The anterior lip of the vessel is everted. The ligature was found in the secretions of the wound. There is no clot in the middle portion, the ends of which are slightly separated, admitting the entrance of granulation tissue for a short distance. There is a purulent infiltration of the media, which has separated it partially from the adventitia, but only a very