Local anæsthesia / by Arthur Schlesinger ; translated by F.S. Arnold.

  • Schlesinger, Arthur.
Date:
1914
Catalogue details

Licence: In copyright

Credit: Local anæsthesia / by Arthur Schlesinger ; translated by F.S. Arnold. Source: Wellcome Collection.

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    Schleich is that around the small ischaemic oedematous area, where the small quantity of concentrated solution lies deposited, a collateral hyperaemia, with increase of blood-pressure, is established, which, by causing pressure from without, forces the cocain into the lymph channels, whereas, where a larger deposit of more dilute solution is in question, this action from without is exerted more gradually, so that absorption is delayed. Simple suction by the lymph-stream is a factor which may, in Schleich’s opinion, be neglected. We cannot agree with this explanation of Schleich’s, for we find that the rule holds also for injections which are not made according to Schleich’s method, and in which oedema and ischaemia of the tissues cannot play any part. Further, it holds also in the case of applications to a mucous membrane, where it is, of course, beyond question that no pressure is exerted on the cocain solution. The following seems to us a far simpler explanation : Let us assume that we have in a cubic centi- metre of a 1 per cent, solution 100 molecules of cocain, then in a cubic centimetre of a 10 per cent, solution we shall have 1,000 molecules. Now, if we inject these two cubic centimetres under the skin of two separate individuals, a fluid deposit of the same size will be formed in each case. In
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