Feebleness of growth and congenital dwarfism : with special reference to dysostosis cleido-cranialis / by Murk Jansen.

  • Jansen, Murk, 1867-1935.
Date:
1921
Catalogue details

Licence: In copyright

Credit: Feebleness of growth and congenital dwarfism : with special reference to dysostosis cleido-cranialis / by Murk Jansen. Source: Wellcome Collection.

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    against the cartilage-cells, which, nevertheless, show no displacement and no change. The vessels are rolled up while growing, and thus give rise to the well-known irregularities in the growth-cartilage. And in less severe conditions, where differentiation is only retarded, not ([nite checked, so that no glomeruli are formed, yet irregularities must ensue from the fact that the cartilage-cells enlarge and disturb the mutual coaptation of cartilage columns and blood-vessels, inasmuch as the widening of the blood-vessels does not keep pace with the enlargement of the cartilage-cells. Ill—FEEBLENESS OF GROWTH CHARACTERIZED BY ENHANCED SENSIBILITY AND ENHANCED FATIGABILITY In one of the preceding sections we have seen that the skeleton which evinces feebleness of growth, differs from the normal skeleton in its reaction to pressure. Where there is feebleness of growth in moderate degree we find a retardation of growth in the growth-cartilages near the knee-—i. e. in those diaphyseo-epiphyseal discs which grow fastest—and particularly in the lateral part which is made to bear pressure surpassing the normal. Where feebleness of growth appears in a severe degree there is a retardation of growth even where functional pressure does not exceed the normal (as in the metacarpal bones), while at the same time the difference of functional pressure in the different parts of any one of the growth-cartilages leads to a retardation on the side most exposed to pressure. Hence the reaction to functional pressure of the skeleton in cases displaying feebleness of growth differs from the normal. In order to obtain a summary view of the different reactions, we will give a graphic representation of the phenomena of growth—of the normal skeleton as well as of that which is affected by feebleness of growth—in relation to functional pressure. By noting down functional pressure on the hori¬ zontal, and growth on the vertical axis, we obtain the following curves (see Fig. 28) : No. I. For the normal skeleton ; No. II. For the skeleton showing slight feebleness of growth (the skeleton which shows excess of height); No. III. For the skeleton with severe feebleness of growth. The continuous parts of these curves are based on clinical observations ; the dotted parts form their inevitable complement. The point n represents normal pressure. The clinical facts on which these curves are based, are the following :