Toxicology / edited by Hans Marquardt [and others].

San Diego ; London : Academic Press, [1999], ©1999.

xxiii, 1,330 : illustrations ; 29 cm

Copy 1. Supplier/Donor: Wellcome Trust Sanger Institute.

pt. 1. Fundamentals. History of toxicology -- Biostatistics in toxicology -- Principles of toxicokinetics -- Xenobiotic metabolism -- Free radicals and reactive oxygen species -- Genetic toxicology -- Chemical carcinogenesis -- Tumor promotion -- Transgenic rodent models -- Receptor toxicology -- Mechanisms of toxicology : programmed cell death (apoptosis) -- Mixtures. pt. 2. Organ toxicity. The liver -- The kidney -- Respiratory tract -- Blood and blood-forming organs -- Immune system -- Skin -- The eye -- Nervous system -- Reproduction and development -- Endocrine system--adrenal cortex, thyroid, and pancreas -- Gastrointestinal tract -- Cardiovascular system. pt. 3. Toxicology of compounds. Hydrocarbons -- Halogenated hydrocarbons -- Fluorocarbons -- Pesticides -- Dioxin and dioxin-like polychlorinated hydrocarbons and biphenyls -- Aromatic amines, nitroarenes, and heterocyclic aromatic amines -- N-nitroso compounds -- Metals -- Gases -- Fibers -- Chemical and biological agents -- Active and passive smoking -- Cosmetic toxicology -- Polymers -- Radiation -- Natural compounds -- Bacterial toxins. pt. 4. Applications of toxicology. Biomonitoring in occupational medicine -- Water -- Risk assessment in environmental remediation -- Ecotoxicology -- Food toxicology : legal aspects -- Food : compound related aspects -- Toxicological evaluation methods for the registration of chemicals -- In vitro methods -- Regulatory toxicology. pt. 5. Risk assessment. Risk assessment and preventive hazard minimization -- Toxicity equivalents and their use in hazard and risk assessment.

Includes bibliographical references and index.