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Hormone replacement therapy.

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A discussion between John Studd from King's College Hospital Medical School and Mr. Geoffrey Chamberlain. The following summary accompanies the cassette: "Following ovarian failure there is a 13-fold increase in plasma FSH and a 3-fold increase in luteinizing hormone together with a fall in oestrone and oestradiol to 20% of their normal follicular phase values. Oestrogen therapy will remove most of the symptoms of the climacteric but there is no doubt that unopposed oestrogens carry a risk of hyperplasmia and possibly endometrial carcinoma. Hyperplasia can be prevented by giving 10 days of a progestogen with the cyclical oestrogen therapy and this should be the recommended regimen of therapy. If cystic glandular hyperplasia does occur with unopposed oestrogens it can invariably be corrected with two 21 day courses of a progestogen. Scanning electron microscopy is being used to characterise the cell surface morphology in normal hyperplastic malignant endometrial cells."


London : University of London Audio-Visual Centre, 1979.

Physical description

1 encoded moving image (29.59) : sound, black and white.



Copyright note

University of London

Terms of use

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

Language note

In English

Creator/production credits

Presented by Mr Geoffrey Chamberlain and Mr John Studd, King's College Hospital, London. Medical editor, Mr Geoffrey Chamberlain, Institute of Obstetrics and Gynaecology, London. Produced by Jennie Smith. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation in association with The Blair Bell Research Society.


This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.


Segment 1 Chamberlain and Studd are seated for discussion. Chamberlain introduces Studd. Studd talks about the latest news in the field of hormone replacement therapy and menopause. Time start: 00:00:00:00 Time end: 00:06:16:00 Length: 00:06:16:00
Segment 2 Studd discusses pre-menopausal symptoms and assesses whether or not oestrogen therapy is useful to treat these symptoms. Time start: 00:06:16:00 Time end: 00:09:58:00 Length: 00:03:42:00
Segment 3 Studd lists and talks about the various pharmaceutical oestrogens available to treat the menopause. He discusses some of the side effects of these medications. Time start: 00:09:58:00 Time end: 00:15:18:00 Length: 00:05:20:00
Segment 4 Studd and Chamberlain discuss the issue of cancer caused by the use of pharmaceutical oestrogens. Time start: 00:15:18:00 Time end: 00:21:20:00 Length: 00:06:02:00
Segment 5 Studd refers to studies on the effectso foestrogen therapy on women with adenomatous hyperplasia. He shows electron micrographs of normal endometrium and endometrium with adenocarcinoma. Time start: 00:21:20:00 Time end: 00:25:03:00 Length: 00:03:43:00
Segment 6 Chamberlain and Studd continue to discuss the risk of cancer while taking hormone replacement therapy and they discuss the results of various research experiments into this field. Time start: 00:25:03:00 Time end: 00:29:59:05 Length: 00:04:56:05


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