Response of ACh receptors to nifedipine

Quail fibroblast cells Ca++ fluorescence - showing how nifedipine blocks the suberyldicholine (SDC) response. A control Ca++ signal. B Response to 10 micromolar SDC, C-G increasing concentration of nifedipine (100pM, 10nM, 1 microM, 10 microM, 100 microM). Credit: Biosciences Imaging Group,Southampton University/Wellcome Trust Medical Photo Library