On the physiological action of carbon monoxide of nickel / John G. McKendrick and William Snodgrass.

  • McKendrick, John G. (John Gray), 1841-1926.
Date:
[1891]
Catalogue details

Licence: Public Domain Mark

Credit: On the physiological action of carbon monoxide of nickel / John G. McKendrick and William Snodgrass. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

    12/18 (page 10)
    This experiment shows tliat the l/30th c.c. (*033) of Ni(CO)4 in '-Ic.c. of aniiydrous chloroform was lethal, and caused a fall of temperature of no less than 9*5°. As it is well known that cliloroform causes a fall of tempera- ture a control experiment was performed in wliich the same quantity of anhydrous chloroform was given as in Experiment 13, but without Ni(CO)4. Experiment 14.—A rabbit, weighing 1342 grms., had at 4 p.m. 10 minims (‘Oc-c.) of anhydrous chloroform introduced below the skin of the back. Temperature of mouih. Remarks. 4.0 38*8 4.25 38-5 4.30 — Rabbit drowsy. 4.35 37-6 5.0 37-3 5.15 36-9 5 30 36T 5.45 35'5 6.0 34-7 6.15 34-3 6.25 34-1 8.30 35-2 Rabbit running about. 9.17 360 9.35 36-0 At 10.45 a.m. next day the temperature was 38‘2°, and the animal was quite well. This experiment sho\\ ed a fall of tempera- ture 4*7° in the course of 2 hours 25 minutes, when the temperarure began to rise, and the normal temperature was regained next morning. In Experiment 13, the temperature had fallen 5° in about the same period of 2 hours 25 minutes, but it continued to fall for 24 hours longer, when it began slowly to rise. The effect of Ni(CO)4 was therefore much greater and more persistent than the effect of the chloroform in which it was dissolved. As Ic.c. of the liquid Ni(CO)4 at 17° C. contains *4470 grm. of nickel, we next studied the action of a corresponding amount of nickei in an aq eons solution of nitrate of nickel of such a strength that Ic.c. contained -4470 grms. of nickel. Two solutions of this in water of the strength res|)ecti\ely of 1 in 300 and of 1 in 20 (the same strength as in Experiment 13) were used. Experiment 15.—A rabbit weighing 1836 grms. had. at 4.30, a temperature in the mouth of 38'9. Ten minims (‘Gc.c.) of