Phagocytosis of red corpuscles / Ludvig Hektoen.

  • Hektoen, Ludvig, 1863-1951.
Date:
[1906]
Catalogue details

Licence: In copyright

Credit: Phagocytosis of red corpuscles / Ludvig Hektoen. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    or opsonic, most commonly both, for human erythrocytes, especially, it would seem, those from patients with certain diseases, e. g., pneu- monia. Phagocytosis without agglutination may occur, but that is rare; agglutination without phagocytosis is more common; agglutina- tion and phagocytosis most common if the serum has any action whatsoever upon the red corpuscles used. This phagocytic and agglu- tinative property of certain sera, especially, so far as my experience goes, of some typhoid patients appears to be lost very slowly on standing (ice-chest). In other sera it may be lost more quickly. TABLE 4. Opsonins and Agglutinins for Human Corpuscles in Human Sera. Phagocytosis and Agglutination by Various Sera Washed Blood Cream + Serum Equal Parts Typhoid F. i Scarlet F. TyphoidF.2 Erysipelas Pneumonia Normal Normal Aggl. Phg. Aggl. Phg Aggl. Phg Aggl. Phg. Aggl. Phg. -^g> Phg Aggl Phg Pneumonic blood cream + + + + + + + + + + + 4- 4-4- 4-4- 4-4- o 4-4-4- Typhoid blood cream... + + + + o o 4-4- ± Scarlet F. blood cream.. + + + + + + ++ + 4- 4-4- 4- Normal blood cream + o 4-4- 4- 4- o o o ♦Erysipelas blood cream 4-4- 4- ♦4-4- ♦4- ♦Pneumonic blood cream 4-4-4- 4-4- 4-4- 4- ♦4-4- ♦4- Rheumatic blood cream o o o o o o Cellulitis blood cream... o o o o o o Normal blood cream.... 4- o 4- 4- 4- o o o o • o Normal blood cream 4-4- 4- 4-4- 4- • Pneumonic blood cream 4-4- 4-4- 4-4- 4-4- Normal blood cream.... o o o o + + + =• phagocytosis well marked. + + — phagocytosis marked. 4- = phagocytosis present. ♦In these cases it concerns serum and blood cream from the same person (autophagocytosis autoagglutination). As indicated the same serum may be opsonic and agglutinating for certain corpuscles but not for others, showing clearly that the condition of the corpuscles may vary greatly. Whether this varia- tion (which I have noticed even in the corpuscles of the same person at different times) may depend on the lack of suitable receptors or upon resistance to the functional group of the agglutinin or opsonin must be determined by further study. As regards the opsonification.