The inborn factors in disease : an essay / by Archibald E. Garrod.

  • Garrod, Archibald E. (Archibald Edward), Sir, 1857-1936.
Date:
1931
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: The inborn factors in disease : an essay / by Archibald E. Garrod. Source: Wellcome Collection.

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    22 THE DOCTRINES OF DIATHESIS medical thought ; and finally the bearings upon medical questions of the modern theories of heredity. In the second section an attempt will be made to apply the newer knowledge to the problems presented by in¬ dividual groups of maladies. In the first place the relation of disease to physical structure will be considered under two heads, namely, the liability of persons of different builds, features, and general conformations to develop particular maladies, and secondly, the influence of structural anomalies and deviations from type, indirectly predisposing to disease. A chapter will be devoted to that most interesting group of hereditary maladies the tissue defects, or abiotrophies as Gowers called them ; some of which do not manifest their presence for years after birth. In another chapter will be discussed the influence of deviations from the average chemical structure and chemical life of the tissues in predisposing to, and shaping the manifesta¬ tions of, some diseases. The inborn factors in infective maladies will call for consideration; and lastly the idiosyncrasies, the remark¬ able sensitivities of some individuals to influences which have no obvious ill effects upon the vast majority of the members of the human race. These range from idiosyn¬ crasies with regard to particular pollens or animal emanations, to grave allergic diseases, such as asthma. The several conclusions reached and inferences to be drawn, will be summed up in an epilogue. It may appear to some that the subjects here dis-