[Texts]

Date:
1971
Reference:
PP/CRI/H/5/1/1
Catalogue details

Licence: In copyright

Credit: [Texts]. Source: Wellcome Collection.

    36/127
    Plausible general reasons can be given why the bands (the control elements) are so large compared to the interbands (the coding elements). A general discussion will be given of the mechanism of formation of the 1 bands. The model adds little to the problem of the logic of control elements discussed by Britten and Davidson, though it is more compatible with their Fig, 1Â than their Fig. IB, The model, in its simplest form, suggests that the number of different proteins normally produced by higher organisms may not be much more than a few thousand for Drosophila and some tens of thousands for man. However e-v it is not concluded that, in special cases, multiple coding sequences may sometimes be hidden within some of the globular bands, in which case the numbers could be higher. This could differ markedly from species to species. Although the model is only a general one and not fully detailed, and although it raises at least as many questions as it answers, I hope it may serve as a focus for discussion and for the design of experiments. In addition to thanking many colleagues for their patience in explaining their results and for discussing these problems with me, especially Sydney Brenner, Leslie Orgel, Peter Walker, Gordy Tomkins and David Baillie, I thank especially the organisers of the specialists' meeting in May of this year at Port Cros for inviting me to attend»,