Licence: Public Domain Mark
Credit: Anaemia. Source: Wellcome Collection.
Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.
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![(they can be readily distinguiHlied i'rom tliese by the iincleuH) or with the lai'<4'e lymphocytes, or else they were all included in one elass. A more exact analysis, howcjver, reveals tliat tljey are totally different cells. These cells stiike the experienced morphological investigator at once as a s])(!c,i;il kind of cell, and the marked essential correspondence with tlio myelocytes is clearly noted. The points which indicate the analogy to the myelocytes are the colour of the staining, the size of the nuclei and its proportion to the protoplasm of the cell. The nucleus usually includes several nucleoli (from two to four), which are well seen when stained by Giemsa. The protoplasm is basophile. At times early granulation of a neutrophilic nature may be seen in these cells, and when stained by Giemsa and triacid stains a large number of every conceivable intermediate form between myeloblasts and myelocytes may be met with. It is quite clear and obvious for many reasons that these cells are not lymphocytes. In the first place, the development of a neutrophile granulation proves that they cannot be cells of lymphatic tissue, since this tissue is not capable under any circumstances of producing neutrophile granules. In the next place, it would be necessary to ascertain where the lymphocytes could come from, since histological research shows that the lymphatic tissue is eliminated and substituted by myeloid tissue. The final proof against the lymphatic nature of these cells is obtained by staining with Schridde-Altmann's dye mixture. These cells stained in this way do not show any fuchsinophile granulation, which is always present in lymphocytes. There are besides biological reasons for deciding that the non-granulated cells must belong to myeloid and not to lymphatic tissue. These cells increase very extensively immediately before death and in acute exacerbations of the disease, as Ehrlich first noticed and as will be described later. It would be most extraordinary if under such conditions a lymphatic cell production should become prominent. Much more probable would be the production of the least mature and most indiiierent form of myeloid cell. This suggestion has actually been made by Turk. However, histolo-](https://iiif.wellcomecollection.org/image/b21223476_0207.jp2/full/800%2C/0/default.jpg)
