On pharmaco-therapy and preventive inoculation applied to pneumonia in the African native : with a discourse on the logical methods which ought to be employed in the evaluation of therapeutic agents / by Sir Almroth E. Wright.

  • Wright, Almroth E. (Almroth Edward), Sir, 1861-1947.
Date:
1914
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Licence: In copyright

Credit: On pharmaco-therapy and preventive inoculation applied to pneumonia in the African native : with a discourse on the logical methods which ought to be employed in the evaluation of therapeutic agents / by Sir Almroth E. Wright. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    Experiment No. V.—Three natives with pneumonia receive Morgenroth's drug : No. 1 a dose of 1 grm. by the mouth ; No. 2 a dose of 1 grm. hypodermically, and No. 3 a dose of 0-5 grm. hypodermically. Dilutions of the pneumococ- cus suspension which were employed r Patient J 80199 r Patient J 60831 j Patient J 1 TTB Bactericidal effect ex- erted after adminis- tration of the drug Before administra- X X X tion Five hours after ad- 0 0 0 ministration Before administra- X X X tion Five hours after ad- 0 0 0 ministration Before administra- X X X tion Five hours after ad- X 0 0 ministration 0 X ^ Serum kills more than I 125 times as many 0 I pneumococci as it ' did before Serum kills more than 25 times as many 0 I pneumococci as it j did before 0 | Serum kills more than I 5 times as many 0 j pneumococci as it J did before 1£ The experiments which have been set forth above make it clear that in man as in mice—but we found that the same did not hold in rabbits—the blood is rendered bactericidal to the pneumococcus by the administration of gethylhydrocupreinhydrochlorate. It is further brought out in Experiment No. 1 and more clearly in Experiment No. 2 that the opsonic power of the serum is not appreci- ably affected by the exhibition of the drug. SECTION II PROBLEM AS TO WHAT LOGICAL METHODS OUGHT TO COME INTO APPLICATION IN ENQUIRIES INTO THE EFFICACY OF THERAPEUTIC AGENTS AS APPLIED IN ACTUAL PRACTICE INTRODUCTION In the case where any one, and a fortiori in the case where all, of the lines of enquiry which have been sug- gested create a presumption in favour of the therapeutic