Volume 3

The haemolytic anaemias, congenital and acquired / by J.V. Dacie.

  • Dacie, John V. (John Vivian), Sir.
Date:
1960-1967
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: The haemolytic anaemias, congenital and acquired / by J.V. Dacie. Source: Wellcome Collection.

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    walls of interlobular arteries and an intense polymorphonuclear reaction was present in the surrounding periarterial tissue. Some of the glomer- uli were totally necrotic and infiltrated with neutrophils; others were infarcted; the majority showed some endothelial proliferation. Similar vascular lesions were seen in arterioles in the adrenals, pancreas and myocardium; in each instance there was destruction and _ fibrinoid necrosis throughout the whole wall of the affected vessel as well as a characteristic periarteriolar inflammatory reaction. Summary. A young boy died of an acute illness simulating acute glomerulonephritis. Necropsy, however, revealed the histological changes of microscopic polyarteritis nodosa. Progression of his illness was associated with a well marked microangiopathic haemolytic anemia. 200 Blood Pressure seco ZEN AY eg bea. tape ES, RR, CR SOR ee eR Tne gS! mmHg. OF > 5 0 | | | esas I 9 Haemoglobin 9./100 ml. 7 5 3 eae 600 Blood Urea mg./ 100ml 4o9 200 0 DAYS Fic. 214. Diagram illustrating the clinical course of, and the lab- oratory findings in, a boy who died of the hzemolytic-uremic syndrome (Case 30). Acute Hemolytic Anemia Associated with Renal Insufficiency in the Newborn A few cases have been described, of obscure origin, in which acute hemolytic anemia associated with azotzemia has developed within the first week of life. Mégevand, Wyss and Thélin (1956) described the