Mutation as cellular process : a Ciba Foundation symposium / edited by G.E.W. Wolstenholme and Maeve O'Connor.

  • Symposium on Mutation as Cellular Process (1969 : London, England)
Date:
1969
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Mutation as cellular process : a Ciba Foundation symposium / edited by G.E.W. Wolstenholme and Maeve O'Connor. Source: Wellcome Collection.

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    INDEX OF SUBJECTS 243 ß-Propiolactone, as mutagen, 50 Protoplasm, role in mutation, 6 Prototrophy, mutations to, effect of caffeine, 36, 42, 46 Psoralen, 177 Pyrimidine dimers, excision, 33, 34 excision from DNA by caffeine, 36, 46, 47 repair, 201 resolved by recombination, 201-202 role in mutagenesis, 18 splitting by photoreactivation, 203 unexcised, elimination by genetic re¬ combination, 199-215 Pyrimidine nucleoside triphosphate, sub¬ strate modifications, 117-121 Pyrimidine-pyrimidine dimers, 126 Pyronin В, 25 Recognition, and recombination, 196 in gene, 209 Recombination, and suppression, 197 avoidance by, 205 comparison with replication, 186-190 effect of fluorouracil, 195 ehmination of unexcised dimers by, 199-215 episomes in, 199, 200, 201, 213-214 in phage T4, 190-191 in yeast, 191-192, 195 recognition and, 196 relation with mutation, 186-198 repair by, 132, 135 resolution of pyrimidine dimers, 201-202 specificity, 188-189 Repair, 231 activation of system, loo-ioi and neutron irradiation, 226 at different cytological stages, 220 by photoreactivation, 99, 203 by recombination, 132, 135, I49. I53 competition with expression, 99-100 damage by irradiation, 219-220 dark, 124, 233 defects in mechanism, 206 enzymes active in, 124-125 enzymic stages, 139 excision, 233 incision enzyme in, 135 Repair, (continued) involvement of nucleases, 127-129 mechanism, 7 of mutational lesions, 96-99 of premutational damage, 225 of pyrimidine dimers, 201 of XO induction, 225 post-replication mechanism, 202 effect of caffeine, 44, 45, 47 size of excised region, 127 under radiation conditions, 217-218 varying capacities for, 220 Repair gene mutants, 18 Replication, comparison with recombina¬ tion, 186-190 Reversion, frequencies, 22-24 genetic change, 30 molecular basis, 29 Revertant cells, resistance to u.V. irradia¬ tion, 53, 55, 62 Riboflavin, 18 Ribonucleic acid, effect of visible Hght on purines, 175 polymerase, m copying adduct of cytosine, 116 reactions directed by modified poly- cytidylic acid template, 114 recognition by, 115,116, 117, 133 reiteration by, 123 radiation effects, 172, 181 mRNA alkylation of, 142-143,145 effect of mutational effects, 181 tRNA, change of pattern, 184-185 irradiation, 183 suppressor, 164, 168 Ribosomes, action of MNNG on, 180 abolition of mis-sense suppression, 160- 161 as guardian of genetic code, 158-165,166 effect of alteration on function, 155-170 nonsense suppression, 158, 163 suppression of mis-sense, 158, 160-161, 163, 168 Ribosome mutations, interaction between, 156-158, 165 loss of curability, 159,163 pleiotropy, 155-156,158 restoration of masked suppression, 161