On urobilin / by F. Gowland Hopkins and Archibald E. Garrod.

  • Hopkins, Frederick Gowland, Sir, 1861-1947.
Date:
[1898]
Catalogue details

Licence: Public Domain Mark

Credit: On urobilin / by F. Gowland Hopkins and Archibald E. Garrod. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    Conclusions from Part II. 1. The hydrobilirubin of Maly although resembling the urobilin of urine and faeces in certain of its properties, differs from it in other respects and notably in containing a far larger proportion of nitrogen. 2. By allowing the action of sodium amalgam upon bilirubin to proceed beyond the stage indicated by Maly a product is obtained which resembles natural urobilin much more closely and which possesses almost identical spectroscopic properties, though we have never obtained from it the E band spectrum described in the first part of this paper. 3. In their elementary composition urinary and faecal urobilin are identical. 4. From analyses of products obtained, from four different supplies of urine and two different supplies of feecal material, for the most part by modifications of the ether-chloroform process, the following mean figures were obtained for the carbon, hydrogen and nitrogen respectively. C 63-58, H 7-84, N 4-11. 5. An estimation of the nitrogen in hydrobilirubin yielded a percentage (9*57) which differs but little from that obtained by Maly (9-22). [The cost of the above investigations was in part defrayed by Grants from the Government Grants'Committee of the Royal Society.]