Report to the Association for the Advancement of Medicine by Research on the relation of micro-organisms to tuberculosis / by W. Watson Cheyne.

  • Cheyne, William Watson, Sir, 1852-1932.
Date:
[1883]
Catalogue details

Licence: Public Domain Mark

Credit: Report to the Association for the Advancement of Medicine by Research on the relation of micro-organisms to tuberculosis / by W. Watson Cheyne. Source: Wellcome Collection.

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    1. On August 1st a rabbit died which was inoculated on July 6th into the eyes with the sixteenth cultivation from a case of spontaneous tuberculosis of a monkey, the first cultiva- tion having been made on October 14th, 1881. In the right eye the point of the syringe was introduced into the anterior chamber and the piston only just touched. In the left eye the point was introduced, but immediately withdrawn again, the piston not being touched. The right eye was seen to be com- pletely converted into a cheesy mass and tubercles were present in the conjunctiva, especially at its reflection. The left eye still showed well-marked tuberculosis of the iris, with commencing caseation at the point of inoculation, and tubercles in the cornea. The glands below the jaw were enlarged and beset with greyish points. The lungs, liver, and spleen were full of minute tubercles. These were largest in the lung where there was commencing caseation at the centre of the nodules with hsemorrhages around the cheesy points. 2. Another rabbit inoculated on the same day with the same material, and in the same manner, was found dying, and was killed on August 1st. The post-mortem appearances were exactly the same as in rabbit No 1. Tubercles cut out of the lung, crushed between two cover glasses and stained by Ehrlich's method, showed numerous bacilli. 3. On August 2nd a third rabbit inoculated in the same manner, at the same time, and with the same material as Nos. 1 and 2, was found dead. The post-mortem appearances were essentially the same, but the tubercles were in the main Hmited to the lungs. 4. On August 5th a fourth rabbit of the same series was killed, and the post-mortem appearances were essentially the same. Tubercles of the lung crushed and examined were found to contain bacilli. There were also other two post-mortems, but as I brought back the organs with me for examination I shall refer to them again. To show me his method of cultivation. Dr. Koch inoculated several tubes of blood-serum as follows -.—(a) Several little flat vessels and tubes were inoculated from a cultivation from the