Handbook of congenital malformations / edited by Alan Rubin.

Date:
1967
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Handbook of congenital malformations / edited by Alan Rubin. Source: Wellcome Collection.

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    ANTIBIOTICS. There is no valid evidence of their teratogenicity in man, but the report by Harley of an association between infantile cataracts and maternal treatment with tetracyclines, other anti¬ biotics, or certain other aromatic drugs demands attention. Tetra¬ cycline during pregnancy may cause yellowing, caries or enamel hypoplasia of infant teeth. See also under Enamel and Dentin, In¬ trinsic Staining and Hypoplasia from Tetracyclines, page 126. Strepto¬ mycin is claimed to be related to impaired hearing in children whose mothers were treated during pregnancy, but the association is not proved. Reference: Harley, J. D., Farrar, J. F., Gray, J. В., and Dunlop, 1. C.: Aromatic drugs and congenital cataracts. Lancet 1:472 (Feb. 29), 1964. Karnofsky, D. A.: Drugs as teratogens in animals and man. Ann. Rev. Pharmacol. 5:447, 1965. Smithells, R. W.: Drugs and human malformations. Advanc. Teratol. 1:251, 1966. Sutherland, J. S., and Light, I. J.: The effect of drugs upon the developing fetus. Pediat. Clin, of N. Amer. Ì2(3): 781, 1965. ANTIMETABOLITES. Many are potent teratogens in experimental animals. Incriminated in man is Aminopterin. This folic acid antag¬ onist, in abortive doses (8 to 20 mg.) taken slightly after the optimal time for abortion (i.e., at six to eight weeks) causes widespread mal¬ formations. Malformations have also been reported following treat¬ ment of leukemic mothers with 6-mercaptopurine and busulfan (Myleran) but they do not necessarily follow. Reference: Sokal, J. E., and Lessmann, E. M.: Effects of cancer chemotherapeutic agents on the human fetus. J.A.M.A. Ì72( 16): 1765, 1960. BUSULFAN (Myleran). See Alkylating Agents, Antimetabolites and Myleran. CARBON MONOXIDE. A number of reports of malformation follow¬ ing maternal carbon monoxide poisoning suggests that this agent may be teratogenic. Reference: Ingalls, T. H.: Environmental Factors in Causation of Congenital Anomalies. Ciba Foundation Symposium on Congenital Malformations. London, J. A. Churchill Ltd., 1960, pp. 51-66. CHLORAMBUCIL. See Alkylating Agents. 366