The synthesis of 3-[beta]-aminoethylindole / by Arthur James Ewins.

  • Ewins, Arthur James.
Date:
1911
Catalogue details

Licence: In copyright

Credit: The synthesis of 3-[beta]-aminoethylindole / by Arthur James Ewins. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    XXXIII.—The Synthesis of 3-/3-Aminoethylindole. By Arthur James Ewins. A very considerable amount of interest has of late centred round a number of amines which may be considered to belong to a special group in that they are derived from the amino-acids of proteins by the removal of carbon dioxide (loss of the carboxyl group). Such bases are often produced by the action of putrefactive organisms on the amino-acids. The earliest examples of this class of bases were discovered by Brieger in the ptomaines, putrescine and cadaverine. Their formation by the action of putrefactive organisms on the correspond- ing amino-acids was first established by Ellinger (Ber., 1899, 32, 3542). Since then amines derived from almost all the known amino-acids have been obtained either by putrefactive processes or by chemical means. The interest attaching to these bases lies in the fact that certain of the more complex amines are possessed of considerable physiological activity, and have been the subject of several recent commu.nications (Barger and Walpole, J. Physiol., 1909, 38, 343; Dale and Dixon, ,/. Physiol., 1909, 39. 25; Acker-