BetaThis search tool is in development. Find out more.
Digital Images

Translocation shown up by cosmid probe

Wessex Reg. Genetics Centre

Available online

view Translocation shown up by cosmid probe

License

Attribution 4.0 International (CC BY 4.0)
You can use this work for any purpose, including commercial uses, without restriction under copyright law. You should also provide attribution to the original work, source and licence.
Creative Commons Attribution (CC BY 4.0) terms and conditions https://creativecommons.org/licenses/by/4.0
Credit: Translocation shown up by cosmid probe. Credit: Wessex Reg. Genetics Centre. Attribution 4.0 International (CC BY 4.0)

Selected images from this work


About this work

Description

Human chromosomes at metaphase, highlighted by fluorescent probes that bind to specific sequences of DNA. This shows the use of such probes in prenatal diagnosis of an unbalanced form of a translocation between chromosomes 4 and 16 (t(4;16). The RT1 cosmid (red) which maps to 16o13.3 can be seen at the end of both short arms of chromosome 16, and also at the tip of the short arm of the der (14) (chromosome 14), thus confirming that the foetus is unbalanced. The 4 and 16 centromeres are labelled in green, and there is some cross-hybridisation to the centromeres of chromosomes 1 and 5. Image by Dr John Crolla.


Permanent link


We’re improving the information on this page. Find out more.