A new method of studying the mammalian heart / by H. Newell Martin.

  • Martin, H. Newell (Henry Newell), 1848-1896.
Date:
[1881]
Catalogue details

Licence: Public Domain Mark

Credit: A new method of studying the mammalian heart / by H. Newell Martin. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    11/16 (page 129)
    The above experiment, as already stated, justifies no conclusions except that an isolated mammalian heart can be kept beating for several hours. It, however, suggests (and subsequent experiments, which I hope shortly to publish, confirm) that the pulse rate of the isolated heart is very independent of arterial pressure, though, as no accurate temperature observations were made in this case, the experiment by itself is not worth much in that respect. Table II. Experiment of May 26, 1881. Time. P. M. Temp, in degrees 0° Pres- sure. Pulse. Notes. 1 h. 50'. 2 h. 05'. 2 h. 15'. 2 h. 45'. 95° • 72 12 92 All vessels tied but those of the coronary and pulmonary circuits. Then 150 c. c. of warm whipped blood sent through the heart in order to wash out the blood al- ready in it and in the lungs. Animal removed to warm cham- ber and the irrigation started from the Marriott’s flasks and maintained thenceforth. Pulse rate not known, as the chronograph was not work- ing. 3 h. 00'. 99° 86 118 3 h. 15'. 98° 87 118 3 h. 55'. 99° 90 120 4 h. 15'. 99° 91 120 4 h. 35'. 100° 87 118 4 h. 50'. 100° 86 120 5 h. 10'. 100° 68 117 5 h. 45'. 100° 64 117 6 h. 00'. 100° 60 118 6 h. 15'. 99° 56 117 Arterial pressure now be^an to fall markedly, and while a fresh supply of blood was being obtained from another dog (that in use having al- ready circulated round the heart many times, and being presumably full of wastes) the organ ceased to beat at 6 h. 45'.