Clinical observations upon the use of antitoxin in diphtheria, and a report of a personal investigation of this treatment in the principal fever hospitals of Europe during the summer of 1895 / by Joseph E. Winters.

  • Winters, Joseph Edcil, -1922.
Date:
1896
Catalogue details

Licence: Public Domain Mark

Credit: Clinical observations upon the use of antitoxin in diphtheria, and a report of a personal investigation of this treatment in the principal fever hospitals of Europe during the summer of 1895 / by Joseph E. Winters. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Record of Dose in Parallel Cases. /—Lesser Amount.—n /—Greater Amount.-^ 1,000 Mild. 2,000 Severe. 2,000 Mild. 3,000 Severe. Case 1 Case 1* Case 1 Case 1 Case 2* Case 2 Case 2 Case 2* Case 3* Case 3 Case 3 Case 3* Case 4 Case 4 Case 4 Case 4 Case 5 Case 5 Case 5 Case 5* Case 6 Case 6 Case 6 Case 6 Case 7* Case 7 Case 7 Case 7* Case 8 Case 8 Case 8 Case 8* Case 9 Case 9 Case 9 Case 9* Case 10 Case 10 Case 10 Case 10* Case 11 Case 11 Case 11 Case 11* Case 12 Case 12* Case 12 Case 12* Case 13 Case 13 Case 13 Case 13 Case 14 Case 14* Case 14 Case 14* Case 15 Case 15* Case 15 Case 15 Case 16* Case 16* Case 16 Case 16* Case 17 Case 17 Case 17 Case 17 Case 18 Case 18 Case 18 Case 18* Case 19 Case 19* Case 19* Case 19 Case 20 Case 20* Case 20 Case 20 Case 21 Case 21 Case 21 Case 21 Case 22 Case 22 Case 22* Case 22 Case 23 Case 24 Case 25 (25—4 died) Case 23 (23—7 died, 30.4 per cent.) Case 23 Case 24 (24—2 died) (22—11 died, 50 per cent.; one died after return home.) 94 cases, 24 deaths, mortality 25.5 per cent. In the two series marked “ severe” the cases were probably of nearly equal severity, inasmuch as they were alternate cases as received into the hospital. There were twenty-three severe cases which re- ceived two thousand units—seven deaths, mortality of 30.4 per cent., and twenty-two severe cases which received three thousand units—eleven deaths, mortal- ity fifty per cent., the mortality being higher wi$i the larger dose of serum in a series of parallel cases. It may be stated that since these experiments no child has received doses of three thousand units. The mortality in children of two years old and * Died.