Some derivatives of 4 (or 5)-methylglyoxaline / by A.J. Ewins.

  • Ewins, Arthur James.
Date:
1910
Catalogue details

Licence: In copyright

Credit: Some derivatives of 4 (or 5)-methylglyoxaline / by A.J. Ewins. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    4(or 5)-M cthyl-b(pr ±)-aminomtthylglyoxalinc CHyCbNBL NH2-CH.,-C—N^011- This base was obtained from 4(or 5)-metbyl-5(or 4)-chloromethyl- glyoxaline by the method employed for the preparation of the fore- going base, using concentrated aqueous ammonia (0'88) in place of methylamme. The yield of base was very poor, amounting to only 10 per cent, of the theory. The picrate crystallises from hot water in clusters of well-formed prisms, melting at 216—217°: 0-0934 gave 0T224 C02 and 0‘0240 HaO. C=35-7; H = 2‘8. C5H9N3,(C6H307N3)2 requires C = 35‘8; H = 26. The hydrochloride crystallises from absolute alcohol in stout, rectangular prisms, melting at 233—234°. Solutions both of this and of the foregoing base give with p-diazo- benzenesulphonic acid an intense cherry-red colour. Ihe greater part of the analytical work in connexion with this investigation has been carried out by Mr. C. J. Gobell, to whom the author wishes to express his thanks. The Wellcome Physiological Research Laboratories, Herne Hill, London, S.E. R. CLAY AND SONS, LTD. BRUNSWICK ST. STAMFORD ST., S.E., AND BUNGAY, SUFFOLK.