Leukaemia cytogenetics / H. Jackson Woodliff.

  • Woodliff, H. Jackson.
Date:
1971
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Leukaemia cytogenetics / H. Jackson Woodliff. Source: Wellcome Collection.

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    CHRONIC GRANULOCYTIC LEUKAEMIA 61 as the Ph chromosome can usually be demonstrated even when bone marrow hypoplasia is induced (Tough et al, 1962; Carbone et ah, 1963; Frei et al, 1964; Speed and Lawler, 1964). Cytogenetic studies are not therefore of practical value in controlling treat¬ ment. Both cytotoxic drugs and radiation can induce chromosomal abnormalities (Fig. 18) which may be added to those due to the Fig. 18.—Post-irradiation chromosome abnormalities. disease itself and these changes may lead to the evolution of a new clone of cells, usually hyperdiploid, which are more malignant and possibly drug-resistant (Pedersen, 1968a). Acute transforma¬ tion may follow. However, this should not be taken as a contra¬ indication to treatment because there is ample evidence to show that this improves the quality of life and length of survival. Ph-positive cells can be removed from the blood by treatment but cytogenetic studies are unnecessary as conventional leucocyte