Leukaemia cytogenetics / H. Jackson Woodliff.

  • Woodliff, H. Jackson.
Date:
1971
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Leukaemia cytogenetics / H. Jackson Woodliff. Source: Wellcome Collection.

    46/168 (page 30)
    30 LEUKAEMIA CYTOGENETICS that one daughter chromosome contains all the material from the short arms, and the other, all the material from the long arms. Such chromosomes are always true metacentrics. The term pseudodiploid is given to those metaphases which have the diploid (2n) number but with one or more atypical chromo¬ somes or additional and missing normal chromosomes, or a mixture of both. Up to 4 per cent of cells from normal cultures may con¬ tain structural changes of one type or another (Nasjleti and Spencer, 1968). If morphological aberrations involving the whole chromosome are present in more than one cell from a single slide or more than 5 per cent of cells from a single specimen, disease or exposure to drugs, chemicals or radiation should be suspected.