Leukaemia cytogenetics / H. Jackson Woodliff.

  • Woodliff, H. Jackson.
Date:
1971
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Leukaemia cytogenetics / H. Jackson Woodliff. Source: Wellcome Collection.

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    LYMPHOMAS 87 Clifford et al, 1968; Gripenberg et ah, 1969). Cytogenetic status may differ in tumours from the same patient and may also be altered by treatment. It has been suggested that tetraploidy may be associated with recurrence after successful chemotherapy. Reticulum cell sarcoma.—The peripheral blood may be normal or show an increase in random aneuploidy. Peripheral blood, bone marrow and ascitic fluid may contain abnormal karyotypes belonging to the same clone as those found in lymphoid tissues (Sasaki et ah, 1965) which frequently but not always contain abnormal cell lines. These include hypodiploid, pseudodiploid, hyperdiploid and near tetraploid metaphases (Sasaki et al., 1965; Miles et al., 1966; Spiers and Baikie, 1968а). There is no close correlation between histology and cytogenetic appearances; how¬ ever, anaplastic tumours tend to be more often in the tetraploid range. Hodgkin's disease.—Cytogenetic studies of peripheral blood are normal, show increased aneuploidy or less commonly an abnormal karyotype in circulating Reed Sternberg cells (Sinks and Clein, 1966). Bone marrow is infrequently involved. Lymphoid tissues often show abnormalities but occasionally normal results are obtained and even where visible aberrations are found an appreci¬ able number of normal metaphases may also be present. An increase in secondary constrictions, the presence of marker chromosomes, hyperdiploidy, pseudodiploidy, hypodiploidy and hypertetraploidy have all been described (Spriggs and Boddington, 1962; Galan et ah, 1963; Baker and Atkin, 1965; Saksela and Ponten, 1968; Spiers and Baikie, 1966,1968a). Of particular interest is the finding of a marker chromosome, an E with deleted short arms in two cases by Spiers and Baikie (1966, 1968ö) and in a further case by Millard and Seif (Millard and Seif, 1967; Millard, 1968). Spiers and Baikie suggested that this chromosome be called M for Melbourne; a similar aberration, and also deletions with the long arms of the E group chromosome, have been found in other histological types of lymphoma and do not therefore neces¬ sarily indicate the Hodgkin's histological type. It might be con¬ sidered as a lymphoma marker as it has not so far been found as an acquired abnormality in any other condition. Prognosis and Treatment Attempts have not been made to correlate cytogenetic findings with survival because of the relatively small numbers of cases