Contributions to the pathology of the glandular structures of the stomach / by William Fox, M.D. ; communicated by A. B. Garrod.

  • Wilson Fox
Date:
1858
Catalogue details

Licence: Public Domain Mark

Credit: Contributions to the pathology of the glandular structures of the stomach / by William Fox, M.D. ; communicated by A. B. Garrod. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

    18/46 page 14
    appears as a rule perfectly homogeneous, without a trace of structure, though I have once or twice observed a faint appearance of striation in it. The change occurs with greatest frequency in the pyloric region, and affects equally the glands lined with a cylindrical epithelium, and those containing spheroidal cells. It is met with also in the neighbourhood of the cardia, and in the glands of the small curvature. I have not found it in the fundus, nor in the left half of the great curvature. (Vide Plate I, figs. 4, 5, and 8.) (3.) The state in which the epithelium of the glands is found is a variable one. It may be apparently normal, though this is extremely rare ; or it may present but little alteration in appearance, except that the cells are smaller and in diminished numbers, or, may be fattily degenerated to a greater or less degree; or, finally, it may be almost entirely absent, its place being occupied by molecular debris and fat-drops. I have not seen it (except when recent catarrh has coexisted) increased in size, nor presenting the granular look, disappearing Avith Liq. Sodje, which is observed in the acute affection. In the more advanced stages, com- plete fatty degeneration seems to be the natural course of the disease, and the state of the glands is thus illustrated by the accompanying drawing (Plate I, fig. 4), exhibiting the appearances presented by a vertical section made in the pyloric region of the stomach of a man dying of phthisis, and who for some time before his death laboured under an almost total anorexia. I am decidedly of opinion, from the progressive series of changes which I have been able to trace, that this accumulation of fat is due to a degeneration of the epithelium. In some cases, where this is most marked, the lower extremities of the glands filled out with fat-drops can alone be seen under the microscope; but I should hesitate to ascribe the disappearance of the upper portion to pathological changes. It is very seldom that the glands can be traced to the surface in a vertical section j they generally appear to terminate in a mass of cells, nuclei.
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