Preliminary experiments on the effect of methionine suplhoximine on the developing chick and on transplantable tumours / by Edward Mellanby.

Edward Mellanby

Date:: [1956?]

Credit: Preliminary experiments on the effect of methionine suplhoximine on the developing chick and on transplantable tumours / by Edward Mellanby. Source: Wellcome Collection.

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4/14 page 267

As it seemed possible that the form in which the sulphur was present in the test substance might be responsible for some of the effects of methionine sulphoximine, a few experiments were made in which sulphur as sulphite, sulphide or sulphate was tested against the saline control. In all experiments the bones grew equally well. Fig. 2. Mean growth curves showing the effect of L-methionine sulphoximine (5 mg/1.) on the growth rate of explanted limb-bone rudiments of chick embryos.-, control bones;-, experimental bones. The femur, tibia and humerus are more severely affected than the radius and ulna. o o X Fig. 3. Mean growth curves of explanted femora, tibiae and humeri of chick embryos, showing that L-methionine sulphoximine (LMS) inhibits growth more than DL-methionine sulphoximine (DLMS).

Preliminary experiments on the effect of methionine suplhoximine on the developing chick and on transplantable tumours / by Edward Mellanby.

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