Volume 1

Gene expression / Benjamin Lewin.

  • Lewin, Benjamin.
Date:
1974-1977
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Gene expression / Benjamin Lewin. Source: Wellcome Collection.

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    CONTENTS SYNTHESIS OF PROTEIN 1 The Genetic Code Equivalence of Gene and Protein ....... 3 definition of the gene ........ 3 nucleic acids as the genetic material ...... 5 colinearity of gene and protein . . . . . . .10 Nature of the Code for Amino Acids . . . . . .13 overlapping and non-overlapping codes . . . . .13 fixed reading frame of the code . . . . . . .16 assignment of codons to amino acids . . . . . .19 Nonsense Codons for Termination ...... 26 suppression of nonsense and missense mutations .... 26 nucleotide sequences of nonsense codons ..... 28 Evolution of the Code ......... 30 universal nature of the code ....... 30 stereochemical interactions in the primitive code .... 33 forces of selection on the code ....... 34 2 Synthesis of the Polypeptide Chain Components of the Apparatus for Protein Synthesis ... .38 sequential synthesis of proteins .38 messenger RNA as the template 40 activating amino acids with transfer RNA ..... 43 the polyribosome complex 46 Addition of Amino Acids to the Polypeptide Chain ... .49 ribosomal sites for transfer RNA. ...... 49 formation of the transfer complex with aminoacyl-tRNA . . 53 binding aminoacyl-tRNA to the ribosome 62 peptide bond synthesis ........ 65 xi