The formation of the corpus luteum in the guinea-pig / Leo Loeb.

  • Loeb, Leo, 1869-1959.
Date:
1906
Catalogue details

Licence: In copyright

Credit: The formation of the corpus luteum in the guinea-pig / Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    central cavity is probably also -the cause thab^ih.ese rows of new-formed cells do not run in an absolutely radial direction, but in a more oblique way. 18. At Twenty-eight and One-Half Hours After Copulation (Celloidin).—Ruptured follicles are prominent over the surface of the ovary at the former place of rupture. The place of rup- ture is covered by large cells (former granulosa and interna cells) with blood vessels. Spindle cells are also present, which perhaps are regenerating cells of the germinal epi- thelium. Near the place of rupture mitoses are seen in the albuginea and also in the endothelial cells of the blood ves- sels. The central cavity is not large and contains a red- staining, granular substance. No line of demarcation between granulosa and theca interna is visible. In the direct neigh- borhood of the theca interna of the developing corpus luteum, blood vessels are dilated and mitoses are present in the endo- thelial cells. The capillaries in the peripheral part of the corpus luteum (in the former theca interna) send out proc- esses toward the central cavity. These capillaries do not yet penetrate deeply into the corpus luteum. Mitoses are present in the endothelial cells of these capillaries and also in many cells in the direct neighborhood of the capillaries. It is some- times difficult to decide whether or not such mitoses belong to endothelial cells. Mitoses are also present in the former granulosa, in cells which have the appearance of granulosa cells, which may nevertheless be immigrated cells. Besides distinct capillaries, we see spindle-shaped cells penetrating into the granulosa. These spindle-shaped cells may in part at least also represent advancing endothelial cells of* capillaries. At some places the tubes formed by the ingrowing spindle- shaped cells (endothelial cells) may extend much further into the corpus luteum. The central part of the corpus luteum, near the central cavity, is free from such cells. The direc- tion of the ingrowing cells is a radial one. In the outer part of the developing corpus luteum many polynuclear leucocytes which stain deeply with eosin are seen. Some karyorrhexis and karyolysis are^ visible in the cells lying in the central cavity. Three developing corpora lutea. 19. At Thirty-one Hours After Copulation (Paraffin).—The corpora lutea are closed; the place of rupture is covered by large cells of the character of granulosa and the large theca interna cells and by regenerating cells, which are probably derived from the germinal epithelium. In one of the develop- ing corpora lutea the follicle forms a marked prominence over the surface of the ovary, the prominence consisting mainly in connective tissue rich in blood vessels. The central cavity has increased in size, cells which have the appearance of de- tached granulosa cells, which show karyolysis and become dis- solved are visible in the central cavity; occasionally a string of cells becomes necrotic. A marked tension seems to exist