A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod.

  • Weber, Frederick Parkes, 1863-1962.
Date:
1903
Catalogue details

Licence: In copyright

Credit: A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    11/86 (page 7)
    The urine was pale in colour, of specific gravity 1020, faintly acid in reaction, and somewhat more viscid than normal. There was sometimes a slight amorphous whitish deposit containing a few crystals of oxalate of lime. There were no casts. The urine contained about 0 83 per cent, (estimated by precipitate with alcohol, drying and weighing) of a proteid which separated out in fiocculi at a temperature of 58° C. On boiling, the precipitate disappeared, in some specimens entirely, reappearing on cooling ; in others it gathered into a viscid mass which floated on the top. Nitric acid gave a precipitate which disappeared partially on heating, and reappeared on cooling. Strong HC1 gave a distinct ring with the urine diluted 1 in 20 (Bradshaw’s reaction). Acetic acid alone gave no precipitate. On the addition of potassium ferrocyanide solution an immediate but not very abundant precipitate appeared. The proteid separated out slowly on prolonged contact with NaCl in excess; NaCl + acetic acid caused a rapid separation. In some specimens the proteid was precipitated by half-saturation with ammonium sulphate, in others only when the salt was added in slight excess. No precipitate appeared on dropping the urine into an excess of distilled water, and it was only partially precipitated on prolonged dialysis. On digestion with pepsin-HCl a considerable residue was left. On an average about 15 grammes of the substance were excreted daily, and the urine contained no other proteid. The total phosphates were estimated on two days with following results : 2. T860 grammes. • Dr. Hutchison added that the total of phosphates excreted was low, but the ratio of earthy to alkaline phosphates was high. He likewise collected some of the pure Bence-Jones proteid from the urine and found it to contain no phosphorus. In this respect, he pointed out, his results agreed with those in most previous cases. I endeavoured on one occasion to find out whether an alteration in the diet of the patient would produce a corresponding alteration in the amount of the Bence- Jones proteid excreted in his urine. For two days (July 26th to 28th, 1900) the patient abstained from Total PoOv 1. 1*173 grammes. Earthy P;05. 0*890 gramme.