The release of histamine by amides and other compounds / MacIntosh, F.C., and Paton, W.D.M.

  • MacIntosh, F. C.
Date:
[1947?]
Catalogue details

Licence: In copyright

Credit: The release of histamine by amides and other compounds / MacIntosh, F.C., and Paton, W.D.M. Source: Wellcome Collection.

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    b XVII INTERNATIONAL PHYSIOLOGICAL CONGRESS 1947 (p. 240-241) Macintosh, P.C., and. Paton 'ft.L.M. (London) Tne release of histamine by amides and other compounds. The trypanocidal diamidines and certain other organic bases have a characteristic effect on the blood pressure of the cat. When one of these compounds is injected intra¬ venously into a cat anaesthetized with chloralose, tiie blood uressure is not immediately affec ced, but sucidenly -lU-lIs after a delay of about 20 seconds. The following evidence irdicates that the delayed depressor effect is due to the release of histamine, (a) Plasma taken^from_a cat after the blood pressure has fallenhas an immediate depressor action when injected into anotner out, ano contracts an isolated strip of guinea-pig’s ileum: the two tests agree as to the ammount of his tomine present in the plasma* (b) The effect oi the post—injection -plasma on both the blood pressure and the gut is not abolished by atropine, but is abolished by neoantergan in doses just sufficient to annul tne efiect of tne ;histamineT (c) The post-injection plasma retains its ;activity when deproteinized and heated with strong hoi, as in Code’s method for estimating histamine in blood. ;< (d) The slow intravenous injection of one of the compounds |elicits a secretion of acid gastric juice in the anaesthetised cat. (e) Injection of dilute solutions o the compounds into human skin produces a typical triple :i responseH. The main site 01 histamine liberation appears to be skeletal muscle. The most active compounds tested were stilbamidine and propamidine. Activity was also jshown by straight-chain diamines, diamidines ana. diguanidines with the basic groups terminally placed, by some aromatic is monoamidines, and by lichenf ormin, -ne antioio ic isolated by Callow and Hart from B, lichenifornns.