Intra-ocular injections of solutions of various antiseptic substances : an experimental inquiry / by G. E. de Schweinitz.

  • De Schweinitz, G. E. (George Edmund), 1858-1938.
Date:
1893
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Licence: Public Domain Mark

Credit: Intra-ocular injections of solutions of various antiseptic substances : an experimental inquiry / by G. E. de Schweinitz. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    mentioned, however, because, as will be remembered, Dr. Berry has found that chlorine water was better tol- erated by the retina and vitreous than other strong antiseptic fluids. These experiments certainly fail to confirm the observations of Ovio, that weak solutions of subli- mate may be injected into the vitreous without caus- ing chronic lesions; that is to say, a solution of 1-5000 will produce as much disturbance as a lotion of 1-500. It seems evident from the experiments that under any circumstance more would depend upon the dose of the drug injected than upon the strength of the solution used. Two minims seem to be much less likely to cause a general clouding of the vitreous than 5 or more minims, but none the less, even in this small dose, in each instance they caused a dense vitreous opacity. In addition to the lesions which were so evident with the ophthalmoscope, the microscope shows that they were not confined alone to the vitreous, and that others, not ordinarily detectable, were present. Thus, according to circumstances, we deal with edema and rarefaction of the choroid; sometimes with its detachment; with detachment of the retina and a type of retinitis analogous to that which is desig- nated proliferans; and with connective tissue for- mation in the vitreous of extensive character. Not only this, but it is interesting to note that in two of the punctures examined there was well-marked her- nia of the choroid. How much such incarceration of this membrane would add to the danger of the treat- ment it is difficult to decide. It is suggestive of the fact that other punctures in operative surgery in this region may be followed by a similar result. The entire failure to check the purulent inflamma- tion called into existence by staphylococci emulsion, by injecting into the vitreous strong solutions of bichloride of mercury, or to prevent its occurrence by a simultaneous injection of a solution of bichloride of mercury, cyanuret of mercury, or aqua chlorinata, is