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Chemorepulsion of DRG sensory neuron

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Description

Sensory neuron from an adult dorsal root ganglion

immunostained for Growth Associated Protein

(GAP43) shown in red. Neurites are growing in

between stripes containing the EphrinA5 protein

(green). When the cell processes come into contact

with this protein they are repelled and therefore

grow along between the stripes. The effects of the

Ephrin molecules are mediated through a family of

tyrosine kinase receptors. The EphrinA5 protein is

important in providing repulsive signals during

the development of the nervous system. Biomedical Image Awards 1999.



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    Credit: Isabella Gavazzi

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