Some new gold salts of hyoscine, hyoscyamine and atropine / by H.A.D. Jowett.

  • Jowett, H. A. D. (Hooper Albert Dickinson)
Date:
[1897.]
Catalogue details

Licence: Public Domain Mark

Credit: Some new gold salts of hyoscine, hyoscyamine and atropine / by H.A.D. Jowett. Source: Wellcome Collection.

    4/8 (page 680)
    water or acetone, and sparingly so in hot and cold alcohol or cold water. On analysis it gave the following results : Found: Gold (i) 29.08 ; (ii) 28.95 cent. Mixed silver haloid salts, 90.4 per cent, of salt taken. Calculated for Ci7H2,N04,HBr,AuClg: Au = 28.60 per cent.; mixed silver salts, 90.2 per cent. The silver salts tested in the usual way were found to contain both chlorine and bromine. In order to be certain that the salt was homogeneous, and also to determine whether, under any conditions, the aurichloride is formed, the experiment was repeated in solutions of varying strength, both acid and neutral, and the percentage of gold in the product determined by ignition. In no case was the aurichloride formed, and except in presence of excess of hydrobromic acid, this new compound was obtained in every case. These results may be tabulated as follows : Percentage of gold Conditions of experiment. found in salt. (i) By mixing concentrated solutions in presence of considerable excess of hydrochloric acid. 28.69 (ii) As above, with specially prepared auric chloride. 28.38 (iii) By mixing 10 per cent, neutral solutions. 28.10 (iv) ,, „ I ,, ,, . 28.10 (v) ,, ,, 0.5 solutions acidified with HCl 28.10 In all the above experiments except (it), the double gold salt of commerce was used, but parallel experiments, with specially prepared auric chloride yielded identical results. In some experiments, the product seemed lighter in colour, but on analysis yielded the same results : Hyoscine auribromide^ Ci7H2iN04,HBr,AuBr3.—When, in place of excess of hydrochloric acid in the above experiment, hydrobromic acid is used, a chocolate-coloured precipitate is formed, which may be recrystal¬ lised from boiling water acidified with hydrobromic acid, when it is ob¬ tained in chocolate-coloured prisms sparingly soluble in cold water. This salt melts with decomposition at about 210®, and on analysis was found to contain bromine but no chlorine, and to be the auribromide of the base. It must thus be formed by the interaction of auric chloride and hydrobromic acid. On analysis, the recrystallised salt gave the fol¬ lowing results : Found : Au (i) 23.68 ; (ii) 23.64 per cent. Br 39.09 per cent. Ci7H2,NO^,HBr,AuBr3 requires Au = 23.93; 39-o7 cent.