Formation of urobilin / by Vaughan Harley.

  • Harley, Vaughan.
Date:
1896
Catalogue details

Licence: Public Domain Mark

Credit: Formation of urobilin / by Vaughan Harley. Source: Wellcome Collection.

Provider: This material has been provided by King’s College London. The original may be consulted at King’s College London.

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    In dog A., where the large intestine had been removed, the faeces appeared to the naked eye to contain large quantities of bile, and bile was always chemically found to be present in large quantities, and though urobilin was fairly present on some days, as a rule it was only found in small quantities. In dog B., on the other hand, the fseces never had a bilious appearance, and analysis always showed either that bile was entirely absent or present only in very small quantities, while urobilin again was always present in abundance. These two animals therefore gave diametrically opposite results, and consequently the results yielded by the aromatic sul- phates, together with what was found at the post-morte?n examination, are of great interest; for by the estimation of the quantity of aromatic sulphates in the urine we are able to recognise the amount of intestinal putrefaction that is going on ; and in dog A., as was found in other dogs without the large intestine, this was markedly diminished. Table shotting the Nitrogen and Sulphate Output by the Urine in the Dogs after removal of their large Intestines. (Both Ani- mals received daily 100 grammes of Lean Meat along with 100 grammes of Biscuit.) Days. Weight of Dog in Kilos. Total Nitrogen in Grammes. Urine Sulphates. Total. Alkaline. Aromatic. Ratio. Dog A. ... I 4 °5 4.427 0.619 A. 0.588 B. 0.032 A. : B. 18 :1 2 4.05 4-815 0.637 O.64O 0.033 19 :1 3 4.05 4.120 o-S55 0.518 0.037 14:1 Dog B. ... 1 5-3° 4.508 0.509 O.449 0.059 7 : 1 2 5-3° 4.no 0.391 0.342 0.049 7 :1 3 5-30 4.461 O.416 0.364 0.051 7 :1 In the above table are only given the results of three days’ analysis in each of the dogs as a type; since the results on other days during which the experiments were continued were in each case similar. In the above two dogs both received exactly the same diet, so that in reality dog B. was receiving less food than dog A. per kilo, weight. However, the difference was small. In normal dogs fed on exactly the same diet the ratio of alkaline to aromatic sulphates I have frequently found to be from 9 to i to 8 to i. In dog A.,