Linkage maps of human chromosomes / Howard Hughes Medical Institute.

Date:
1987
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Linkage maps of human chromosomes / Howard Hughes Medical Institute. Source: Wellcome Collection.

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    of the results of the thousands of likelihoods that are calculated in such analyses has proven exceptionally burdensome. For this reason an intelligent database system consisting of the results of the likelihood calculations has been developed and combined with an automated system of analysis. III. Progress Report This collection of abstracts and chromosome linkage maps constitutes a preliminary progress report from the Utah linkage group. As such, the data reported herein should be regarded as provisional and likely to be revised in detail, although not in substance. Because significant differences between male and female recombination frequencies have been observed, the analyses include a preliminary look at the question of sex specific map distances. However, the reader should take careful note that the analyses of sex specific map distance are indeed very preliminary and have been carried out only under the assumption of a constant ratio of sex specific map distance for each chromosome. We fully expect that further examination will often reveal regions of intrachromasomal heterogeneity in this ratio, as has been found for both chromosomes 11 and 12. The great majority of our marker loci lie within chromosomally assigned linkage groups. However, a signifi¬ cant number of markers are as yet unassigned and are likely to fall within the sparsely populated regions of a few chromosomes. In particular, the genotyping of a number of very informative VNTR markers is still in progress and is expected to add a number of strong anchor points to the maps. Even with that, however, most chromosomes are now well described; the probability of linkage of an unknown marker with one of the linkage groups is now well over 90%. A