Linkage maps of human chromosomes / Howard Hughes Medical Institute.

Date:
1987
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Linkage maps of human chromosomes / Howard Hughes Medical Institute. Source: Wellcome Collection.

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    segregation patterns already characterized for a large number of marker loci by other investigators in these families. An investigator need, therefore, only develop the segregation pattern of his marker locus in the СЕРП families in order to map his marker locus with respect to many other marker loci. Ultimately, for high resolution studies with tightly linked markers, even more families than the Cfc:Pi! collection are reguired and we routinely type the entire collection of 59 families available to us. As shown in the accompanying abstract, the complete set of Ь9 reference families does represent an adeguate panel for fine structure mapping. C. Chromosome Assignment of Linkage Groups through Assigned Genes Family studies develop linkage groups, but do not reveal their chromosomal assignment. However, if even only one member of the linkage group has been assigned to a chromosome, it specifies the chromosomal location of the entire linkage group. We have, therefore, taken care to include in our linkage studies a number of gene loci that have been previously assigned to a chromosome or that were assigned as part of a collaborative effort. D. Marker Order Determined by Rational Strategy The linkage groups that form the chromosome maps are often now continuous with over 20 linked marker loci. The number of calculations reguired to determine the most favored gene order by brute force would be 20!/2. Even with new, high speed algorithms for the calculation ol likelihoods, it has proven useful to develop methods that permit the exclusion of broad classes of marker orders that are clearly not favored. Furthermore, keeping track 3